Journal Club: clinical

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Journal Club: clinical

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Did Vaccine Change Cause Global Spread of AMR Pertussis?

Link Between Less Antigenic Vaccines and AMR Bordetella pertussis

Bordatella Vaccine Development

20 Nov 2025 Lora Benoit Ph.D

A possible link between a less antigenic form of the whooping cough vaccine and global transmission of antimicrobial resistant B. pertussis is explored by Xu et al., 2025 in their analysis of 1,774 genomes isolated from China, Japan, US, and France.
Clinical & Veterinary

Rapid Point-of-Care Detection of STIs CT/NG/MG

Study Supports Shift Toward POC Molecular Diagnostics for STIs

Chlamydia Mycoplasma genitalium Neisseria

20 Nov 2025 Lora Benoit Ph.D

The Cobas Liat molecular POC assay delivers rapid results in 20 min and specificities >97% for Chlamydia trachomatis, Neisseria gonorrhoeae, and Mycoplasma genitalium (MG), and sensitivities ≥92% regardless of symptomatic status.
Clinical & Veterinary

Syndromic Respiratory Pathogen Panel Multicenter Evaluation

Study on LIAISON PLEX Respiratory Flex Assay

Bordatella Diagnostic Systems Influenza

20 Nov 2025 Lora Benoit Ph.D

A multicenter evaluation confirms that the LIAISON PLEX Respiratory Flex Assay delivers robust, clinically reliable detection of up to 19 respiratory pathogens, supporting its integration into routine diagnostic use.
Clinical & Veterinary

Spray-on Biocide Durability Claims a Bust in the Real World

Study on Effects of Spray-on Biocide

Sanitizers Surface Monitoring

18 Nov 2025 Lora Benoit Ph.D

Commercially available spray-on surface biocide (SAQAS) showed no significant antimicrobial effect at either 5- or 30-day post-application under real world conditions.
Food & Beverage Clinical & Veterinary

Microbiome-informed Diagnostic for Clostridioides difficile Infection

Clostridioides difficile

Clostridioides difficle

17 Nov 2025 Lora Benoit Ph.D

Gut microbiome profiles can be used to distinguish C. difficile colonized patients with diarrhea from those with true CDI infections.
Clinical & Veterinary

Multiplex PCR Detects Resistance Genes from Blood Cultures

Detection of Resistance Genes in Blood Cultures by Multiplex PCR

Antibiotic Resistance Blood Culture Journal Club

17 Nov 2025 Lora Benoit Ph.D

Marxreiter et al. (2025) benchmarked a rapid multiplex PCR assay against microdilution susceptibility testing, demonstrating how effectively molecular detection of resistance genes mirrors phenotypic resistance in Gram-negative pathogens.
Clinical & Veterinary

Comparison of Three Rapid Antimicrobial-Susceptibility-Testing Systems

Comparison of Rapid AST Systems like VITEK REVEAL

Antibiotic Resistance Antimicrobial Susceptibility Testing Journal Club

17 Nov 2025 Lora Benoit Ph.D

Squitieri et al. (2025) have conducted a head-to-head comparison of 3 rapid antimicrobial-susceptibility-testing (AST) systems applied directly to Gram-negative blood cultures in a clinical microbiology setting.
Clinical & Veterinary

Rapid Serotyping of Salmonella via MALDI-TOF and Machine Learning

Serotyping Salmonella Using MALDI-TOF and AI

Artifical Intelligence Journal Club MALDI-TOF

05 Nov 2025 Lora Benoit Ph.D

Study shows that combining MALDI-TOF MS with machine learning (XGBoost) can accurately identify Salmonella serotypes. This combined approach might soon provide diagnostic labs with a rapid and cost-effective approach to resolving Salmonella serotypes.
Food & Beverage Clinical & Veterinary

What Microbiology Labs Need to Know About Updates to Antimicrobial Resistance Testing in CLSI M100

Antimicrobial Resistance Testing in CLSI M100

Antibiotic Resistance Journal Club

15 Oct 2025 Lora Benoit Ph.D

In the new CLSI M100 edition, major updates were introduced - including restructured tables, new breakpoints, and a tiered approach to reporting.
Clinical & Veterinary

Everything You Need to Know About Equipment Validation for Sterility Testing

Sterility Testing of Cell and Gene Therapy Products

ATMP - Advanced Therapeutic Medicinal Products Cell and Gene Therapies Journal Club

14 Oct 2025 Lora Benoit Ph.D

As novel biologics and cell therapies advance, sterility testing is becoming increasingly complex and subject to cGMP scrutiny. Gebo et al. outline how clinical microbiology labs - traditionally CLIA/CAP-regulated - can align with FDA, USP, and ISO expectations.
Clinical & Veterinary Pharmaceutical

How Klebsiella pneumoniae Evolves and Persists in the Clinical Setting

How K pneumoniae Evolves and Persists in Clinical Setting

Journal Club Klebsiella pneumoniae carbapenemase (KPC)

13 Oct 2025 Lora Benoit Ph.D

Study on Klebsiella pneumoniae clone that evolved within patients over a 5-year hospital outbreak: virulence, capsule, iron scavenging, and biofilms shifted independently across hosts - highlighting how multidrug-resistant pathogens rapidly adapt and persist under clinical pressures.
Clinical & Veterinary

Tracing 20 Years of Salmonella Dublin Evolution: Human, Animal, Environmental Sources

Salmonella Spread Risk From Livestock

Journal Club Salmonella

04 Nov 2025 Lora Benoit Ph.D

In one of the most comprehensive studies of its kind, a genomic analysis of 2,150 Salmonella Dublin isolates collected in the U.S. over 20 years reveals strong genetic similarity among isolates from human, cattle, and environmental reservoirs.
Clinical & Veterinary

Design of a Host-directed Adjuvant to Sensitize Intracellular Bacterial Persisters to Antibiotics

Intracellular Bacterial Persister Cells Contribute to Antibiotic Failure

Antibiotic Resistance Mycobacterium tuberculosis Salmonella Typhimurium

03 Nov 2025 Lora Benoit Ph.D

Lu et al., (2025) describes the discovery and characterization of a non-toxic small-molecule adjuvant, K1, which modulates the host cell in such a way as to resuscitate metabolically dormant intracellular bacteria making them become sensitive to antibiotics.
Clinical & Veterinary

Comparison of cgMLST Pipelines for Hospital Outbreak Detections

Comparison of cgMLST Pipelines for Hospital Outbreaks

Whole Genome Sequencing

03 Nov 2025 Lora Benoit Ph.D

Three commercial cgMLST pipelines were compared, using 255 hospital outbreak isolates, evaluating their concordance in identifying outbreak-related clusters and whether they consistently distinguish “clustered” vs “non-clustered” isolate pairs.
Clinical & Veterinary

Phage Cocktail Tailored to Treat Hospital Acquired Enterobacter cloacae Complex Infections

Multi-phage Formulations Attack Enterobacter cloacae complex

Coliphages Enterobacter Cloacae Complex (ECC)ESKAPE Pathogens

03 Nov 2025 Lora Benoit Ph.D

Study demonstrates that an institution-specific phage cocktail, built using local strain surveillance, can reduce time-to-effective therapy, curb transmission of resistant clones, and limit off-target ecological effects compared with broad, non-targeted antimicrobial agents.
Clinical & Veterinary

Blood Culture Contamination and Blood Culture Practices in US Hospitals: Time for Standardization?

Blood Culture Contamination

Blood Culture Journal Club Preanalytics

28 Oct 2025 Lora Benoit Ph.D

In one of the most comprehensive evaluations of its kind, Fabre et al. (2025) show striking variability in how hospitals define, measure, and act on blood culture contamination data, highlighting the need for national standardisation of definitions and reporting metrics.
Clinical & Veterinary

Invasive Fungal Diseases Are On The Rise

Climate Change Increasing Concern for Invasive Fungal Pathogens

Candida auris Journal Club

08 Oct 2025 Lora Benoit Ph.D

Konkel Neabore argues that rising temperatures, extreme weather events, and ecological disruption are accelerating the emergence, spread, and virulence of human fungal diseases. Mounting evidence links climate change to fungal adaptation and pathogenicity.
Clinical & Veterinary

Staphylococcus aureus Complex for the Clinical Microbiologist

Staphylococcus aureus Complex for the Clinical Microbiologist

Journal Club Staphylococcus aureus

01 Oct 2025 Lora Benoit Ph.D

A recent review examines the Staphylococcus aureus complex (SAC) - its clinical relevance, diagnostic challenges, and implications for epidemiology and infection control.
Clinical & Veterinary

Exploring the Salivary Virome in Childhood Dental Caries

Salivary Virome in Childhood Dental Caries

Journal Club Streptococcus

01 Oct 2025 Lora Benoit Ph.D

A recent study by Tang and Baker investigates the salivary virome in children with dental caries, revealing a diverse viral community and its potential role in oral health.
Clinical & Veterinary

Is the Raw Milk Movement Posing A Dangerous Zoonotic Threat?

Zoonotic Risk of Avian Flu in Raw Milk

Avian Influenza Dairy Journal Club

15 Sep 2025 Lora Benoit Ph.D

The crossover of avian influenza A(H5N1) to dairy cattle and the recovery of virus in milk from infected cows pose a risk for human transmission. Whilst pasteurization is known to inactivate the virus, the increasing popularity of raw milk consumption has led to concerns.
Food & Beverage Clinical & Veterinary

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