Journal Club: clinical

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Journal Club: clinical

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Candida auris: High-Resolution Detection of Healthcare Transmission Using WGS

Candida auris Detection and Antifungal Resistance Using WGS

Antibiotic Resistance Candida auris Whole Genome Sequencing

20 May 2026 Lora Benoit Ph.D

A new study uses WGS to define healthcare-associated transmission clusters of Candida auris and identify antifungal resistance determinants. SNP-based thresholds combined with epidemiologic data enable accurate outbreak reconstruction and prediction of resistance-associated mutations.
Clinical & Veterinary

Journal Club - 13 May to 18 May

Journal Club

Antimicrobial Resistance (AMR)Carbapenemase-Resistant Enterobacterales (CRE)Hantavirus

18 May 2026 Lora Benoit Ph.D

Latest from our Journal Club: understanding hantavirus, why wastewater has a role in antimicrobial resistance, how synthetic biology is reshaping gut microbiome research, and mechanisms of the spread of carbapenem resistance in enterobacterales.
Water Clinical & Veterinary Microbiome

Hantavirus - What Do You Need to Know?

Key Information on Hantavirus Infections

Hantavirus

13 May 2026 Lora Benoit Ph.D

This review of six publications on Hantavirus delivers key information points all healthcare professionals should know. Current concern centers on a cruise-associated cluster of Andes virus infections, a rare Hantavirus uniquely capable of person-to-person transmission and severe disease.
Clinical & Veterinary

Mechanisms of Carbapenem Resistance Spread in Enterobacterales

Mechanisms of Carbapenem Resistance in Enterobacterales

Antibiotic Resistance Antibiotic Stewardship Carbapenemase-Resistant Enterobacterales (CRE)

13 May 2026 Lora Benoit Ph.D

This 2026 review synthesizes current knowledge on the molecular epidemiology and transmission dynamics of blaNDM-5-harboring IncX3 plasmids, a key driver of Carbapenem-resistance in Enterobacterales (CRE).
Clinical & Veterinary

Comparison of 3 Commercial AST Testing of Burkholderia cepacia Complex

Comparative analysis of 3 commercial AST for B cepacia Complex

Antibiotic Sensitivity Burkholderia cepacia complex (BCC)

08 May 2026 Lora Benoit Ph.D

Study compares 3 clinical antimicrobial susceptibility testing (AST) systems - Vitek 2, Sensititre, and Etest, against reference broth microdilution (rBMD) method for Burkholderia cepacia complex (BCC), identifying substantial inter-platform variability across methods.
Clinical & Veterinary

Rapid Detection of Salmonella using a RPA–CRISPR/Cas12a Platform

Salmonella enterica detection using a RPA CRISPRCas12a Platform

CRISPR LAMP/Isothermal Amplification Salmonella

07 May 2026 Lora Benoit Ph.D

Novel diagnostic system for rapid detection of Salmonella enterica that combines isothermal nucleic acid amplification with CRISPR-based collateral cleavage to enable highly sensitive and specific detection.
Food & Beverage Clinical & Veterinary Assay Development

Journal Club - 27 April to 12 May 2026

Journal Club

Antibiotic Sensitivity Artifical Intelligence Burkholderia cepacia complex (BCC)

12 May 2026 Lora Benoit Ph.D

Latest from our Journal Club: Variability in AST systems for Burkholderia cepacia complex, AI-integrated biosensors for rapid pathogen detection in complex food systems, CRISPR-based diagnostic platform enabling rapid, sensitive detection of Salmonella enterica.
Food & Beverage Clinical & Veterinary Assay Development

Journal Club - 26 April to 5 May 2026

Journal Club

Blood Culture Candida auris Hospital Acquired Infection (HAI)

05 May 2026 Lora Benoit Ph.D

Latest from our Journal Club: Polymicrobial Dysbiosis drives Noma, Yeast ID methods, antifungal susceptibility testing (AST) practices, and C. auris screening, and Rapid, accurate sepsis diagnostics, using the Molecular Mouse.
Clinical & Veterinary Microbiome

Novel Syndromic Sepsis Panels Show High Accuracy for Rapid ID of Bloodstream Pathogens

Syndromic Sepsis Panels Shows Accuracy for IDing bloodborne pathogens

Blood Culture Gram-negative bacteremia Sepsis

02 May 2026 Lora Benoit Ph.D

Using the Molecular Mouse (MM) Sepsis panels (Alifax, Padova, Italy), 144 residual positive blood culture samples from non-replicated patients were analysed, comparisons were made with a typical methodology that includes cultures, MALDI-TOF MS, AST, and RT-PCR.
Clinical & Veterinary

Yeast ID, Antifungal Susceptibility Testing, and Candida auris Screening at US Hospitals

Survey of mycology-related practices at US hospitals

Candida auris Hospital Acquired Infection (HAI)Yeasts and Moulds

02 May 2026 Lora Benoit Ph.D

This survey-based study evaluated yeast identification methods, antifungal susceptibility testing (AST) practices, and C. auris screening strategies across US hospitals.
Clinical & Veterinary

Polymicrobial Dysbiosis Characterizes the Oral Microbiome in Noma

Polymicrobial dysbiosis in the oral cavity of children with noma

Metagenomics

02 May 2026 Lora Benoit Ph.D

Shotgun metagenomic sequencing of oral samples from children with noma revealed a distinct polymicrobial dysbiosis, characterized by enrichment of anaerobic and opportunistic pathogens, supporting a community-driven disease model.
Clinical & Veterinary Microbiome

Journal Club - 16 April to 25 April 2026

Journal Club

Antibiotic Sensitivity Salmonella Whole Genome Sequencing

29 Apr 2026 Lora Benoit Ph.D

Latest from our Journal Club: Salmonella rates in retail meats, with evidence of multidrug resistance and links to human infections. Faster antimicrobial susceptibility testing and how hospital genomic surveillance can enable earlier identification of transmission chains.
Clinical & Veterinary

Thermoreversible Poloxamer Media Enables On-demand Agar Dilution-equivalent AST

Thermoreversible poloxamer media offers alternative to Standard Agar for AST

Agar Agar Dilution Panel Antibiotic Sensitivity

25 Apr 2026 Lora Benoit Ph.D

Poloxamer dilution provides a practical, on-demand alternative to agar dilution, delivering comparable MIC accuracy while simplifying laboratory workflow and improving reproducibility.
Clinical & Veterinary

Real-time Genomic Surveillance Enables Early Hospital Outbreak Detection

Real-Time Genomic Surveillance Saves Money and Lives for Hospitals

Hospital Acquired Infection (HAI)Whole Genome Sequencing

25 Apr 2026 Lora Benoit Ph.D

Routine real-time WGS surveillance identified previously unrecognized hospital outbreaks, reduced transmission, and demonstrated significant cost savings, supporting integration of genomic surveillance into standard infection prevention programs.
Clinical & Veterinary

Journal Club - 10 April to 15 April 2026

Journal Club

Blood Culture Mycobacterium tuberculosis

20 Apr 2026 Lora Benoit Ph.D

Latest from our Journal Club: how blood culture practices across Europe impact sepsis diagnostics, opportunities to improve blood culture sampling compliance, and a comparison of the diagnostic performance of paired saliva and oral swab samples for molecular TB testing.
Clinical & Veterinary

Variability in Blood Culture Practices Across Europe Limit Sepsis Diagnostic Readiness

Variability in blood culture collection practices that drive poor sepsis diagnosis

Blood Culture Sepsis

15 Apr 2026 Lora Benoit Ph.D

A Europe-wide cross-sectional survey revealed major disparities in blood culture practices, laboratory capacity, and diagnostic infrastructure necessary for optimal sepsis diagnosis.
Clinical & Veterinary

Interventions Driving Improvements in Blood Culture Collection Quality and Timing

Scoping review of interventions aimed at improving blood culture collection

Blood Culture Sepsis

15 Apr 2026 Lora Benoit Ph.D

This scoping review synthesizes the findings of 25 interventional studies published over 10 years aimed at improving blood culture sampling compliance and reducing contamination rates.
Clinical & Veterinary

Saliva-Based Testing Meets WHO Targets for Tuberculosis Diagnostics

Saliva-based Molecular Testing for TB is a viable option

Mycobacterium tuberculosis Swabs Molecular Assay

15 Apr 2026 Lora Benoit Ph.D

Molecular testing of saliva using Xpert MTB/RIF Ultra demonstrated high diagnostic sensitivity and specificity for pulmonary tuberculosis, outperforming oral swabs and satisfying WHO performance targets for non-sputum diagnostic specimens.
Clinical & Veterinary

Journal Club - 2 April to 9 April 2026

Journal Club

Bacillus cereus Probiotics Toxins

14 Apr 2026 Lora Benoit Ph.D

Latest from our Journal Club: B. longum ssp. infantis EVC001 reduces NEC in preterm infants, improved cereulide detection in powdered formula, and new models on how temperature, pH, and water activity drive cereulide production by Bacillus cereus.
Food & Beverage Clinical & Veterinary Microbiome Assay Development

Probiotic EVC001 in Preterm Infants Reduces Incidence and Severity of NEC

Reduction of necrotizing enterocolitis in preterm infants given probiotic

Probiotics

09 Apr 2026 Lora Benoit Ph.D

B. longum ssp. infantis probiotic strain EVC001 reduces incidence of necrotizing enterocolitis in premature babies.
Clinical & Veterinary Microbiome

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