Journal Club

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Read key findings from selected peer reviewed published papers in journal club

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Microbial Identification a rapidmicrobiology Special Focus

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Journal Club

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New Enrichment Broth Finds B.cereus in Half of Powdered Infant Foods Sampled

Improved Recovery of B cereus From Infant Formulas

Assay Validation Bacillus cereus Toxins

09 Jan 2026 Lora Benoit Ph.D

Using a novel enrichment (R & F® Bacillus cereus Group Enrichment Broth) and detection scheme, researchers found B.cereus group species in 50 per cent of PIF and infant cereal samples. WGS and cytotoxicity assays confirmed the presence of potentially virulent strains.
Food & Beverage Assay Development

BACTEC Validated for Sterility Testing of ATMP Suspensions

BACTEC can be used for sterility testing of ATMP Suspensions

ATMP - Advanced Therapeutic Medicinal Products Cell and Gene Therapies Sterility Testing

02 Jan 2026 Lora Benoit Ph.D

The BACTEC automated microbial detection system reliably detects low-level contamination (≥ 5 CFU) in stem cell products suspended in Ringer’s Lactate, demonstrating full concordance with pharmacopeial sterility testing while delivering significantly faster results.
Assay Development

2-Day Sterility Testing for Cell-Based Therapeutics

Rapid and reliable sterility testing of ATMP

ATMP - Advanced Therapeutic Medicinal Products Cell and Gene Therapies Sterility Testing

02 Jan 2026 Lora Benoit Ph.D

Using an automated blood culture system, researchers demonstrated that mesenchymal stem cell (MSC) therapeutic preparations can be reliably screened for microbial contamination within 48 hr, supporting substantially faster product release compared with conventional 14-day sterility testing.
Pharmaceutical

Prevalence of Salmonella in Lymphatic Tissues of US Pigs

Lymphatic tissue is a significant Salmonella reservoir in US hogs

Salmonella Smarter Food Safety

02 Jan 2026 Lora Benoit Ph.D

A study of 6 US cull hog processing facilities found Salmonella in tonsils and mesenteric lymph nodes of boars, sows, and gilts, with >59% of carcasses positive in at least one lymphatic tissue, highlighting internal tissues as a key contamination reservoir.
Food & Beverage

Metagenomic Next Generation Sequencing (mNGS) Outperforms Culture in Detecting Lung Pathogens

Using mNGS for difficult to culture lung pathogens

Metagenomics Next Generation Sequencing (NGS)

27 Dec 2025 Lora Benoit Ph.D

In clinical lower respiratory tract infection samples, metagenomic NGS demonstrates higher overall detection rates and superior identification of co-infections compared with conventional culture, while agreeing closely with Sanger sequencing results.
Clinical & Veterinary

Antibiotics Shape Upper Respiratory Tract (URT) Microbiome in Recurrent Otitis Media

Antibiotics and age influence the microbiome in recurrent ear infections

16S Antibiotic Stewardship Microbiome

27 Dec 2025 Lora Benoit Ph.D

Study highlights the dynamic interplay between host age, antibiotic exposure, and the upper respiratory microbiome in children prone to recurrent acute otitis media.
Clinical & Veterinary Microbiome

16S-Based Metagenomic NGS Improves Detection of Pathogens

Evaluation of 16S-Based Metagenomic NGS

16S Assay Validation Next Generation Sequencing (NGS)

27 Dec 2025 Lora Benoit Ph.D

Targeted 16S metagenomic Next-Generation Sequencing (Next-Generation Sequencing) identifies pathogens in ~74% of culture-negative clinical samples, improving diagnostic yield over conventional methods and revealing diverse bacterial species, including fastidious and anaerobic organisms.
Clinical & Veterinary

Pharmaceutical Contamination Remains a Quality Challenge

Contamination of medicinal products is an ongoing industry issue

Endotoxin Sterility Testing

19 Dec 2025 Lora Benoit Ph.D

Despite stringent regulations and pharmacopoeial standards, contamination of both sterile and non-sterile products continues to be an issue, with documented incidents and outbreaks linked to bacteria, fungi, as well as endotoxin exposures, highlighting ongoing manufacturing challenges.
Clinical & Veterinary

Importance of Validating Recombinant Endotoxin Reagents

Validation Needed When Replacing LAL With rFC Endotoxin Tests

Assay Validation Endotoxin Kinetic Colorimetric Assay (KCA)

19 Dec 2025 Lora Benoit Ph.D

Recombinant endotoxin reagents offer sustainable, animal-free endotoxin testing alternatives, but manufacturers must validate them against autochthonous or indigenous microbial flora from their own environments to ensure accurate detection.
Clinical & Veterinary

Automated AST by Colibri and WASP Matches Manual Accuracy

Fully automated AST testing for the clinical microbiology laboratory

Antibiotic Sensitivity Assay Validation Automation

19 Dec 2025 Lora Benoit Ph.D

Automated bacterial suspension preparation with Colibri® combined with plate streaking by WASP® demonstrates high categorical agreement with manual methods for antibiotic disk diffusion susceptibility testing, supporting its use in total laboratory automation.
Clinical & Veterinary

Improving ESBL Recovery in Healthcare Environmental Samples

Improved recovery of ESBL-producing bacteria using chromogenic agar

Antibiotic Resistance Carbapenemase-Resistant Enterobacterales (CRE)Chromogenic Media

19 Dec 2025 Lora Benoit Ph.D

Recovery of ESBL-producing E. coli and K. pneumoniae from healthcare environmental samples is optimized by 18-hour pre-enrichment in buffered peptone water followed by plating on cefotaxime-supplemented Membrane Lactose Glucuronide Agar.
Clinical & Veterinary

Flow Cytometry Reveals Hidden Microbes in Dialysis Water

VBNC Bacteria in Dialysis Water Detected by Flow Cytometry

Flow Cytometry Viable But Not Culturable (VBNC)

13 Dec 2025 Lora Benoit Ph.D

A direct comparison of flow cytometry and heterotrophic plate count methods shows that culture-based testing substantially underestimates microbial contamination in dialysis water.
Clinical & Veterinary

Viable But Non-Culturable (VBNC) Pathogens in Drinking Water May Pose Health Risks

VBNC Pathogens in Potable Water

E. coli Pseudomonas aeruginosa Viable But Not Culturable (VBNC)

13 Dec 2025 Lora Benoit Ph.D

Viable But Non-Culturable (VBNC) E. coli and P. aeruginosa are prevalent across source, tap, and potable drinking water even after treatment. Predictive models suggest health risks from these VBNC pathogens exceed acceptable thresholds.
Water

IceGut Study Maps Early-Life Gut Microbiome Trajectory

Babys Gut Health Linked to Maternal Pregnancy Complications

Microbiome

06 Dec 2025 Lora Benoit Ph.D

Fecal microbiome profiling from 328 Icelandic children and their 214 mothers reveals a unique early-life gut colonization and a durable perinatal imprint from mothers affected with maternal gestational diabetes mellitus.
Other Microbiome

Shedding Light on 'Low Endotoxin Recovery' in LAL Assays

Low Endotoxin Recovery in LAL Assays

Clinical Trials Endotoxin Pyrogen Free Labware

04 Dec 2025 Lora Benoit Ph.D

Excipients used in pharmaceutical formulations can induce endotoxin masking, causing the Limulus Amebocyte Lysate (LAL) assay to underestimate true endotoxin levels. Gorman et al. show that masking arises from excipient-driven alterations in endotoxin structure and aggregate size.
Clinical & Veterinary Assay Development

Human Transmission of Invasive Nontyphoidal Salmonella

Human Transmission of Invasive Nontyphoidal Salmonella

Microbial control Salmonella Enteritidis Salmonella/Shigella

04 Dec 2025 Lora Benoit Ph.D

Phylogenomic and epidemiological analyses of invasive non-typhoidal Salmonella (iNTS) indicate that >50% of infections - historically considered foodborne or zoonotic - arise from human-to-human transmission, with diarrheal patients acting as intermediaries.
Clinical & Veterinary

Reconstituted Infant Formulas Contain Viable Microorganisms

Bottle containing reconstituted infant formula

Bacillus cereus Smarter Food Safety Yeasts and Moulds

04 Dec 2025 Lora Benoit Ph.D

Powdered Infant Formula (PIF) reconstituted using sterile 70°C water, sterile room-temperature water, or a common at-home preparation machine (AHPM) contains viable bacteria and yeast, indicating that conventional reconstitution guidance may not guarantee microbiological safety.
Food & Beverage

Infant Botulism on the Rise; an Outbreak in the US

FDA Recalls ByHeart Infant Formula Due to Possible C botulinum

Clostridium botulinum

20 Nov 2025 Lora Benoit Ph.D

A 2025 study by Dabritz et al. shows infant botulism is on the rise; in Nov 2025, a Clostridium botulinum outbreak has been linked to the ByHeart brand of infant formula in the US.
Food & Beverage

Did Vaccine Change Cause Global Spread of AMR Pertussis?

Link Between Less Antigenic Vaccines and AMR Bordetella pertussis

Bordatella Vaccine Development

20 Nov 2025 Lora Benoit Ph.D

A possible link between a less antigenic form of the whooping cough vaccine and global transmission of antimicrobial resistant B. pertussis is explored by Xu et al., 2025 in their analysis of 1,774 genomes isolated from China, Japan, US, and France.
Clinical & Veterinary

Improved Method to Predict Salmonella Heat Inactivation

Estimating Salmonella Inactivation in Low Moisture Foods

HACCP Salmonella Smarter Food Safety

20 Nov 2025 Lora Benoit Ph.D

A new modelling approach to estimate Salmonella inactivation in low-moisture foods under non-isothermal elevated-heat conditions involves tracking temperature changes in real-time and applying sequential kinetic modelling.
Food & Beverage

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Read key findings from selected peer reviewed published papers in journal club

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Microbial Identification a rapidmicrobiology Special Focus

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Plan your escape from the lab with the rapidmicrobiology event listings

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