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Journal Club - 13 May to 18 May

Summary: Latest from our Journal Club: understanding hantavirus, why wastewater has a role in antimicrobial resistance, how synthetic biology is reshaping gut microbiome research, and mechanisms of the spread of carbapenem resistance in enterobacterales. 
This 2026 review synthesizes current knowledge on the molecular epidemiology and transmission dynamics of blaNDM-5-harboring IncX3 plasmids, a key driver of Carbapenem-resistance in Enterobacterales (CRE).
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This 2026 review explores the ways in which synthetic biology is reshaping gut microbiome research, enabling the rational design of engineered commensal bacteria, synthetic gene circuits, and microbial consortia for therapeutic and diagnostic applications.
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A greenhouse mesocosm study found that wastewater residuals can promote the persistence and spread of antibiotic resistance genes (ARGs) through soil, water, plants, and earthworms, highlighting wastewater reuse in the dissemination of antimicrobial resistance in the environment. 
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This review of six publications on Hantavirus delivers key information points all healthcare professionals should know. Current concern centers on a cruise-associated cluster of Andes virus infections, a rare Hantavirus uniquely capable of person-to-person transmission and severe disease. 
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This week’s Journal Club explores what clinicians should know about hantavirus, why wastewater has a role in antimicrobial resistance, how synthetic biology is reshaping gut microbiome research, and mechanisms of the spread of carbapenem resistance in enterobacterales.