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Journal Club: assay-development

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Novel Test Strategy for Highly Pathogenic Avian Influenza A

Testing for Bird Flu using combined molecular approach
Assay DevelopmentAssay ValidationAvian Influenza
10 Jan 2026 Lora Benoit Ph.D
By combining FDA-authorized clinical and research-developed RT-PCR assays, researchers enabled adaptable, cost-effective diagnostics and large-scale surveillance for highly pathogenic avian influenza A H5.
Clinical & Veterinary Assay Development

New Enrichment Broth Finds B.cereus in Half of Powdered Infant Foods Sampled

Improved Recovery of B cereus From Infant Formulas
Assay ValidationBacillus cereusToxins
09 Jan 2026 Lora Benoit Ph.D
Using a novel enrichment (R & F® Bacillus cereus Group Enrichment Broth) and detection scheme, researchers found B.cereus group species in 50 per cent of PIF and infant cereal samples. WGS and cytotoxicity assays confirmed the presence of potentially virulent strains.
Food & Beverage Assay Development

BACTEC Validated for Sterility Testing of ATMP Suspensions

BACTEC can be used for sterility testing of ATMP Suspensions
ATMP - Advanced Therapeutic Medicinal ProductsCell and Gene TherapiesSterility Testing
02 Jan 2026 Lora Benoit Ph.D
The BACTEC automated microbial detection system reliably detects low-level contamination (≥ 5 CFU) in stem cell products suspended in Ringer’s Lactate, demonstrating full concordance with pharmacopeial sterility testing while delivering significantly faster results.
Assay Development

Shedding Light on 'Low Endotoxin Recovery' in LAL Assays

Low Endotoxin Recovery in LAL Assays
Clinical TrialsEndotoxinPyrogen Free Labware
04 Dec 2025 Lora Benoit Ph.D
Excipients used in pharmaceutical formulations can induce endotoxin masking, causing the Limulus Amebocyte Lysate (LAL) assay to underestimate true endotoxin levels. Gorman et al. show that masking arises from excipient-driven alterations in endotoxin structure and aggregate size.
Clinical & Veterinary Assay Development

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