Summary: Latest from our Journal Club: updated CLSI guidance on CRE, WGS predicts Isoniazid resistance in Mycobacterium tuberculosis complex, analysis of 2022 U.S. infant formula crisis, foodborne pathogen transmission, microbiome effects after antibiotic use, and AI-enabled Gram stain results.
FYI: The updated CLSI M100 (2025) guidance recommends the reintroduction of routine carbapenemase testing for carbapenem-resistant Enterobacterales in addition to MIC susceptibility interpretation.
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WGS (Whole Genome Sequencing) can accurately predict isoniazid (INH) resistance in Mycobacterium tuberculosis complex isolates, demonstrating high sensitivity and specificity and enabling a reduced phenotypic testing algorithm without compromising resistance detection.
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New study analyzes the 2022 U.S. infant formula shortage and recovery using integrated measures of retail in-stock rates, sales data, and household survey responses.
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The Reoccurring, Emerging, and Persisting (REP) strain framework is a new surveillance model that uses WGS and epidemiologic patterns to identify pathogens responsible for illnesses occurring over extended periods rather than discrete outbreaks.
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A large population-based study demonstrates that oral antibiotic use is associated with long-lasting changes in gut microbiome composition, with measurable effects persisting for up to 8 years after exposure, particularly following certain antibiotic classes.
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A new study demonstrates that combining digital holographic microscopy (DHM) with artificial intelligence (AI) enables rapid, automated digitization and interpretation of blood culture Gram stains.
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This week's Journal Club Explores: updated CLSI guidance on carbapenem resistant enterobacterales (CRE), WGS to predict Isoniazid resistance in mycobacterium tuberculosis complex, new study analyzes the 2022 U.S. infant formula shortage and recovery, a new framework for understanding long-term foodborne pathogen transmission, evidence for long-term microbiome effects after antibiotic use and AI-enabled digital holographic microscopy for automated gram stain interpretation.
