Summary: Latest from our Journal Club: comparing rapid phenotypic AST platforms, approaches to resolving genotype–phenotype discordance, and proposed breakpoint adjustments to improve reliability of disk-diffusion.
New study compares the VITEK REVEAL AST System and the Accelerate Pheno System for rapid AST directly from Gram-negative positive blood cultures. Across 128 specimens and 1,410 organism–drug pairs, both systems demonstrated high agreement and delivered actionable results in under 8 hours.
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This report describes a case of S. aureus bacteremia where rapid genotypic testing detected methicillin resistance while initial phenotypic AST indicated susceptibility. The authors demonstrate a practical approach to resolving genotype–phenotype discordance.
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This study re-analyzed a large panel of anaerobes to assess how disk-diffusion methods classify susceptibility under CLSI, CA-SFM, and EUCAST breakpoints. The authors identified discrepancies and proposed breakpoint adjustments to improve reliability, highlighting challenges for anaerobic bacteria.
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This week's Journal Club Explores: Comparative analysis of rapid phenotypic antimicrobial susceptibility testing (AST) platforms, focuses on methods to address genotype-phenotype discordance, and suggestions of breakpoint adjustments to enhance the reliability of disk-diffusion tests.
