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Journal Club - 11 March to 20 March 2026

Summary: Latest from our Journal Club: Community- and hospital-acquired septic shock, timing of Metagenomic NGS-guided antibiotic adjustment (mNGS), and nanopore-based targeted next-generation sequencing to detect M. tuberculosis.
This multicenter prospective study evaluated nanopore-based targeted next-generation sequencing to detecting M. tuberculosis and drug resistance directly from non-sputum specimens.
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This retrospective multicenter study evaluated how timing of Metagenomic NGS-guided antibiotic adjustment (mNGS) impacts patient mortality in ICU patients with severe community-acquired pneumonia.
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New study compares community- and hospital-acquired septic shock, demonstrating that acquisition setting shapes pathogen profiles, host immune responses, and treatment outcomes, with important implications for diagnosis, therapy, and prognosis.
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This week's Journal Club Explores: community- and hospital-acquired septic shock, how timing of Metagenomic NGS-guided antibiotic adjustment (mNGS) impacts patient mortality, and nanopore-based targeted next-generation sequencing to detect M. tuberculosis and drug resistance.