QC laboratories today face increasing pressure to meet sustainability goals while delivering performance, efficiency, and throughput. Lonza’s sustainable QC ecosystem brings together sustainable reagents, validated automation, and industry-standard data solutions to help reduce QC risk, strengthen supply security, and enable confident decision-making.
The Monocyte Activation Test (MAT) has gained increasing adoption as companies move toward more sustainable testing options. Modern methods such as MAT and recombinant Factor C assays are now recognized as reliable, resource-efficient approaches for detecting both endotoxins and non-endotoxin pyrogens. As animal-based pyrogen tests are phased out, MAT is becoming the leading in-vitro standard.
Lonza’s PyroCell® MAT Systems provide a sustainable alternative for detecting endotoxins and non-endotoxin pyrogens. Lonza offers flexible, validated system options designed to meet product-specific and sustainability requirements. These systems utilize human immune cells to deliver accurate and reliable results, supporting testing of complex biologics, including vaccines and gene therapies.
Even with advanced in-vitro methods, endotoxin masking remains a key challenge that can lead to false-negative results and compliance risks. In a collaborative study conducted by Lonza and Solvias, the teams demonstrated how PyroCell® MAT combined with the PYROSPERSE® Dispersing Agent can enhance pyrogen detection in challenging matrices. For teams looking to better understand endotoxin masking and its impact on MAT performance, the on-demand webinar “Disrupting endotoxin masking in the Monocyte Activation Test” provides practical insights grounded in this study and real-world testing experience.
Lonza is your partner in advancing sustainable, reliable, and efficient QC testing. We help you reduce QC risk, strengthen supply security, and confidently meet your sustainability goals.
