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11th February 2015  Content supplied by: Check-Points Health B.V.

Identify CPE Carriers and Confirm Suspected CPE in 2 Hours


Check-Direct CPE is a rapid molecular detection test for detection of Carbapenemase-Producing Enterobacteriaceae (CPE), covering the most clinically prevalent carbapenemases - KPC, OXA-48, VIM and NDM - including the emerging OXA-181 variant.

The test gives accurate results in 2 hours directly from rectal swabs or cultures with the limit of detection < 5 copies/PCR reaction for KPC, OXA-48, VIM and NDM.

Sample preparation is performed using the NucliSENS® easyMAG® for rectal swabs and crude extraction for cultures, followed by amplification and detection on the ABI 7500, CFX96TM, LightCycler® 480 system I & II, Rotor-Gene Q.

Check-Direct CPE is also available on the fully automated BD MAXTM System.

Benefits Include:

  • Speed - clear cut results in just 2 hours with genotypic confirmation.
  • Versatility - identify CPE carriers directly from rectal or perianal swabs and confirm suspected CPE from routine clinical cultures.
  • Specificity - has been tested with 19 different strains of KPC, 25 different strains on OXA-48, 17 different strains on NDM, 34 different stains of VIM.  No positive results when tested against 87 non-carbapenemase producers.
  • Sensitivity - < 5 copies/PCR reaction for KPC, OXA-48, VIM and NDM.

    

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Date Published: 11th February 2015

Source article link: http://check-points.com/downloads/Check-Direct_CPE_flyer_01.pdf


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