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13th January 2022 Content supplied by: CD Genomics
Microbiome Research with Comprehensive Sequencing Solutions
CD Genomics is a leading services company committed to providing global customers with the most comprehensive analytic services, including a broad range of microbial genomic solutions to support research and development. The company announced microbiome profiling services, alongside bioinformatic analysis technology to help researchers understand the significance of human and animal microbiota.
Through long-term and detailed studies of the gut microbiota, scientists have revealed the complex relationship between human and gut microbes. Scientists have found that the dysbiosis of gut microbiota is linked to malnutrition, obesity, diabetes, and various other diseases.
Researchers who worked on a joint project among Columbia University Medical Center, Albert Einstein College of Medicine, and St John's University sought to elucidate the mechanisms by which maternal consumption of a high-fat diet leads to a dysregulated immune response and, subsequently, spontaneous preterm birth.
"We performed 16S ribosomal RNA sequencing of DNA extracted and amplified from stool samples and compared the gut microbiomes of lipopolysaccharide-induced pregnant mice that were maintained on a high-fat diet compared to a normal control diet. Next, we sequenced the uterine transcriptomes of the mice. To test the effect of dampening of the immune response on the microbiome, transcriptome, and risk of spontaneous preterm birth, we induced immune tolerance with repetitive subclinical doses of endotoxin and performed 16S ribosomal RNA and uterine transcriptome sequencing on these immunotolerized mice," introduced by the researchers, "To evaluate the diversity of gut microbiota and the RNA transcriptome of uteri, we sent stool samples and uteri to CD Genomics for 16S RNA sequencing and RNA-sequencing, respectively."
"We can help you study the human microbiota from the intestine, mouth, skin, urine, reproductive tract, etc., to better understand human health and diseases. The microbial sequencing strategies we have adopted include: amplicon sequencing, metagenomic sequencing, PacBio SMRT Sequencing, Nanopore sequencing, and so on, "said the chief scientist of CD Genomics." Among them, amplicon sequencing is a highly targeted method (sequencing PCR products of a specific region or captured fragments), which is used to analyze gene variations in specific genomic regions. Amplicon sequencing is an efficient and cost-saving method. For example, 16S RNA sequencing is suitable for rapidly depicting the microbiome landscape. CD Genomics uses a variety of Illumina next-generation sequencing platforms to fulfill your various research needs. "
"Our sequencing technologies intend to assist basic research and microbiology-based innovation, including Biomarker Discovery, Drug Discovery and Development, Microbial Innovations, and Personalized Medicine. We're happy to help you harness the potential of this promising area, "said Dianna, Marketing Manager of CD Genomics.
Date Published: 13th January 2022
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