« Previous article
The Evolution of Ste...

11th February 2019  Content supplied by: Merck Millipore

In vitro Pyrogen Detection of Both Endotoxins and NEPs: Application Note

The Monocyte Activation Test (MAT) is currently the only in vitro method designed for the detection of both endotoxins and non-endotoxin pyrogens (NEPs). Using the Mono-Mac-6 (MM6) cell line as a source of monocytes, the PyroMAT® test mimics the human immune reaction to pyrogens to measure the pyrogenic effect of parenteral products. 

This new solution has been evaluated with samples such as albumin, fetal bovine serum, and vaccines, and our latest application note demonstrates the effectiveness of the PyroMAT® system with hormone-based drugs.

In this study we describe a range of suitability tests performed on the following selection of injectable hormone drugs. 


To read the method, results and analysis, download our application note.

With the PyroMAT® system, we offer a robust and sensitive solution for pyrogen detection supported by international regulations and guidelines to reduce animal consumption for pyrogen tests.

Make the move today.

Share on:


Date Published: 11th February 2019

Source article link: View

View full company details





Tel: +[49] 6151 72-0

Email Supplier

View full company details

Related news from Merck