In vitro Pyrogen Det...
ISO 9308-1: Testing ...
5th March 2019 Content supplied by: Merck Millipore
Testing for Endotoxins? Don’t Underestimate the Risk of Non-Endotoxin Pyrogen Contamination
Testing for endotoxins? Don’t underestimate the risk of non-endotoxin pyrogen contamination.
The PyroMAT® system is a Monocyte Activation Test (MAT) for the detection of both endotoxin and non-endotoxin pyrogens in parenteral drugs and medical devices.
Unlike the rabbit pyrogen test and bacterial endotoxin test, also known as the LAL Test, the PyroMAT® system does not require the use of animals. In addition, due to its ability to detect a broad range of pyrogens, the PyroMAT® system is clearly differentiated from the LAL test which can only be used to detect endotoxins (a specific type of pyrogen coming from Gram-negative bacteria).
Several MAT solutions based on human blood derived products from donors are available on the market, but with our new PyroMAT® system, we bring a major innovation by using a human monocytic cell line (namely the Mono-Mac-6 cell line) as a source of monocytes. This innovation brings a very robust and standardized method with high sensitivity. Thanks to a ready-to-use system including monocytic cells and a software-based data analysis tool, we ensure ease of use and an optimized workflow in the lab.With the PyroMAT® system, we offer a significant step forward in the MAT market for the detection of a broad range of pyrogens and a move away from animal-based tests. Discover more:
Date Published: 5th March 2019
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In vitro Pyrogen Detection of
ISO 9308-1: Testing for E.