In this BioTechniques Talking Techniques podcast, recombinant protein engineering expert Yuning Chen, R&D Manager at Sino Biological discusses the key applications of these proteins, the aspects of certain products that make them difficult to produce and how these difficulties can be overcome. Yuning also reveals how the manipulation of antibodies has been essential to multiple aspects of our response to the COVID-19 pandemic.

After a review of the recent evolutions in protein engineering, from cell-free systems to automation, Yuning describes his vision for the future of the field and reveals his support for the “Terminator-style” uprising of AI and advanced automation techniques that he believes could revolutionize it.

Contents:

• The production of recombinant proteins
• Key applications
• What makes some proteins difficult to produce?
• Overcoming these challenges
• Manipulating antibodies to take part in multiple aspects of pandemic response
• The most exciting applications of engineered proteins
• Developments in high throughput and automated protein engineering
• Cell-free protein engineering
• The benefits of cell-free systems
• What is next for recombinant protein production?
• The dream of automation for the recombinant protein production

About the Speaker

Yuning Chen, Ph.D. R&D Manager at Sino Biological, Inc. Dr. Chen received his Ph.D. in protein biochemistry from Ohio University in 2012 and completed his post-doc training in protein biochemistry and biophysics from The Pennsylvania State University in 2016. During his academic training, Dr. Chen participated in multiple projects funded by NSF and DOE. He is highly experienced in recombinant protein expression, purification, and biochemical characterization with an outstanding track of publications in top journals. Dr. Chen currently holds the position of R&D Manager at Sino Biological, Inc. and is responsible for strategic design of recombinant protein products development and custom project oversight.

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