Speed-oligo®, Complete, Simple PCR-based Diagnosis for Whooping Cough
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Bordetella pertussis is the microorganism which causes the whooping cough; a very contagious infectious disease worldwide spread that affects mainly children aged 0 to 4. It is usually lethal for breast-fed children.
Nowadays, whooping cough is becoming a major health problem due to several factors:
- Progressive loss of vaccine effectiveness over time
- Decreasing protection against this disease in some communities
- Atypical presentation of the disease leading to a low suspicion rate on the doctor's side
- Change in the average age of presentation
It includes three tests lines:
Culture isolation is the reference technique in Bordetella research, although it is technically complex and offers low sensitivity. Even if the serology is a reliable technique, samples obtained during the acute stage and the convalescence are required; which is difficult sometimes. Moreover serology is not appropriate to distinguish between infection and vaccination.
Due to its application in clinical diagnosis, PCR technique has become the reference technique.
SPEED-OLIGO® BORDETELLA is an oligochromatographic test for the qualitative detection and differentiation of Bordetella pertussis and Bordetella parapertussis in clinical samples.
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- Test line specific to B. parapertussis (corresponding to a selected target inside insertion sequence IS1001).
- Test line corresponding to the insertion sequence IS481. It increases the sensibility of the test since it is a repeated sequence in the B. pertussis genome.
- Test line that amplifies the specific fragment of the ptxA gene promoter, exclusive to B. pertussis and provides higher specificity to the product.
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